The closest airports in the area are the Southwest Florida International Airport (RSW) located about 41 miles north of Marco Island in Fort Myers, Florida, Page Field (FMY) located approximately 45 miles north of Marco Island in Fort Myers, Florida, the Charlotte County airport (PGD) located roughly 69 miles north of Marco Island in Punta Gorda, Florida, and the Airglades airport (2IS) located around 69 miles northeast of Marco Island in Clewiston, Florida.

Further airports which may cost less include Miami International Airport (MIA) located 97 miles east of Marco Island, and Tampa International Airport (TPA), located 178 miles north of Marco Island.